HU-210 CAS NO: 112830-95-2

HU-210 shine (-) enantiomer na 11-OH-D 8-THC-DMH, wanda ke da kusan dukkanin ayyukan cannabinoids, yayin da (+) eantiomer, wanda ake kira HU-211, ba shi da aiki a matsayin cannabinoid, amma yana aiki maimakon a matsayin cannabinoid azaman mai adawa da NMDA tare da tasirin neuroprotective.

Hu-210 na iya inganta yaduwar, amma ba bambanta, sel na al'adu na al'ada ta kunna CB 1 Mai karɓar CB 1 Mai karɓar CB 1 Regontor, da alamar erk a tsaye.Wannan haɓakar haɓakar jijiyoyi kuma yana nuna buƙatar anti-damuwa da tasirin cutarwa.

Tare da sauran cannabinoids na roba, irin su WIN 55,212-2 da JWH-133, HU-210 yana kare kariya daga kumburi da cutar Alzheimer ta haifar da beta amyloid, baya ga hana rashin fahimta da asarar alamun neuronal.Wannan tasirin anti-mai kumburi yana haifar da kunnawa na masu karɓar cannabinoid, wanda ke hana kunna ƙwayoyin microglia mai kumburi.Bugu da kari, cannabinoids gaba daya kawar da neurotoxicity hade da microglial cell kunnawa a cikin bera model.

HU-210 shine maganin kashe zafi mai ƙarfi wanda ke da tasiri iri ɗaya da THC na halitta.

LD50 na baki na HU-210 shine 5,000mg/kg a cikin berayen da 14,200mg/kg a cikin zomaye.LDLO (mafi ƙarancin kisa) na HU-210 a cikin mutane shine 143mg/kg.An kiyasta LD50 na maganin kafeyin ya zama 150-200 mg/kg.Delta-8-THC LD50 ba a tabbatar da shi ba.A cikin binciken 1973, birai da karnuka da aka ba 9,000 mg/kg na Delta-8-THC ba su da kisa.